CaMK-II activation is essential for zebrafish inner ear development and acts through Delta–Notch signaling
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چکیده
منابع مشابه
The transmembrane inner ear (Tmie) protein is essential for normal hearing and balance in the zebrafish.
Little is known about the proteins that mediate mechanoelectrical transduction, the process by which acoustic and accelerational stimuli are transformed by hair cells of the inner ear into electrical signals. In our search for molecules involved in mechanotransduction, we discovered a line of deaf and uncoordinated zebrafish with defective hair-cell function. The hair cells of mutant larvae fai...
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Bone morphogenetic protein (Bmp) signaling has long been known to be important for the early development of the ventral mesoderm, including blood, vasculature and kidney cells. Although Bmp genes are continually expressed in the ventral cells throughout gastrulation and somitogenesis, previous studies in zebrafish have not addressed how the role of Bmp signaling changes over time to regulate ve...
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4:45PM Claire Cordella Language-based strategies for subtyping of patients with primary progressive aphasia PI: Brad Dickerson, Massachusetts General Hospital A subset of the Cambridge Semantic Battery (CSB) testing category comprehension was administered to thirty-six subjects with a diagnosis of primary progressive aphasia (PPA). Subjects’ diagnoses were of three subtypes: agrammatic PPA, log...
متن کاملHistone deacetylase 1 is required for the development of the zebrafish inner ear
Histone deacetylase 1 (HDAC1) has been reported to be important for multiple aspects of normal embryonic development, but little is known about its function in the development of mechanosensory organs. Here, we first confirmed that HDAC1 is expressed in the developing otic vesicles of zebrafish by whole-mount in situ hybridization. Knockdown of HDAC1 using antisense morpholino oligonucleotides ...
متن کاملZona Pellucida Domain-Containing Protein β-Tectorin is Crucial for Zebrafish Proper Inner Ear Development
BACKGROUND The zona pellucida (ZP) domain is part of many extracellular proteins with diverse functions from structural components to receptors. The mammalian β-tectorin is a protein of 336 amino acid residues containing a single ZP domain and a putative signal peptide at the N-terminus of the protein. It is 1 component of a gel-like structure called the tectorial membrane which is involved in ...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2013
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2013.05.028